منابع مشابه
Tetrahydrobiopterin levels regulate endothelial cell proliferation.
Vascular abnormalities, including altered angiogenesis, are major factors contributing to the morbidity and mortality of diabetes. We hypothesized that impaired angiogenesis in diabetes results from decreased tetrahydrobiopterin (BH4)-dependent synthesis of nitric oxide (NO) by endothelial cells (EC). To test this hypothesis, we utilized EC from spontaneously diabetic BB (BBd) and nondiabetes-p...
متن کاملA key role for tetrahydrobiopterin‐dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin‐deficient mice
BACKGROUND AND PURPOSE The cofactor tetrahydrobiopterin (BH4) is a critical regulator of endothelial NOS (eNOS) function, eNOS-derived NO and ROS signalling in vascular physiology. To determine the physiological requirement for de novo endothelial cell BH4 synthesis for the vasomotor function of resistance arteries, we have generated a mouse model with endothelial cell-specific deletion of Gch1...
متن کاملTetrahydrobiopterin: mediator of endothelial protection.
During the past twenty years, the essential role of endothelial cells in preservation of vascular homeostasis has been well established.1,2 Protection of the vascular endothelium against harmful influences of circulating substances including excessive levels of lipids has been a major therapeutic approach in prevention of atherosclerosis. While endothelial dysfunction, defined as a loss of biol...
متن کاملTetrahydrobiopterin and Endothelial Dysfunction in Cardiovascular Diseases
Endothelial vasodilator dysfunction is a characteristic feature of patients at risk for coronary atherosclerosis. We have reported that insulin resistance may be a pathogenic factor for endothelial dysfunction through impaired endothelial nitric oxide synthase (eNOS) activity and increased oxidative breakdown of nitric oxide (NO) due to an enhanced formation of superoxide anion, which are cause...
متن کاملTetrahydrobiopterin: important endothelial mediator independent of endothelial nitric oxide synthase.
Tetrahydrobiopterin (BH4), an essential cofactor for diverse cellular processes, is present in almost every cell or tissue of higher organisms. BH4 has well-defined functions in terms of enzymatic activities (BH4 is a crucial cofactor for the aromatic amino acid hydroxylases and all isoforms of nitric oxide synthase [NOS]) but has other less-defined functions in cells. BH4 is a growth or prolif...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Research
سال: 2007
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.107.162503